10.1006/gcen.1995.1040.Baudry A, Lamothe B, Bucchini D, Jami J, Montarras D, Pinset C, Joshi RL: IGF-1 receptor as an alternative receptor for metabolic signaling in insulin receptor-deficient muscle cells. 2010, 28 (5): 511-515. Genome Biol. The venom of Geography Cone Snail is a complex mix of hundreds of different toxins that is delivered through toxoglossan radula, a harpoon-like tooth propelled from an extendable proboscis. “We found that the geography cone only injects this lethal venom when it … 1981, 256 (10): 4734-4740.Johnson CR, Stablum W: Observations on the Feeding Behavior of Conus geographus (Gastropoda: Toxoglossa). In the absence of medical intervention, 70% of human stinging cases are fatal.
: The expression levels are shown for each conotoxin in each segment, represented as number of reads aligned to the toxin. 1971, 25 (1): 109-111.Olivera BM, Miljanich GP, Ramachandran J, Adams ME: Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins. J Biol Chem. Biochemistry. 1984, 259 (23): 14343-14346.Olivera BM, McIntosh JM, Cruz LJ, Luque FA, Gray WR: Purification and sequence of a presynaptic peptide toxin from Conus geographus venom. Gen Comp Endocrinol. The geography cone snail is highly dangerous; live specimens should be handled with extreme caution. Just because human deaths are uncommon, it doesn’t mean you should throw away caution.
2003, 278 (5): 3137-3144.
Search 1990, 215 (3): 403-410.Zdobnov EM, Apweiler R: InterProScan–an integration platform for the signature-recognition methods in InterPro. High on the list is another marine animal and Australian native, the geographic cone snail. 10.1016/j.cbpa.2003.12.004.Kaas Q, Westermann JC, Halai R, Wang CK, Craik DJ: ConoServer, a database for conopeptide sequences and structures.
This toxin blocks N-type calcium channels (Cav2.2/CACNA1B) with a high potency (it displaces [125I]GVIA with an IC(50)=3.7-38 pM) (PubMed:10938268, PubMed:11724570). 10.1016/j.ygeno.2006.06.014.Pi C, Liu Y, Peng C, Jiang X, Liu J, Xu B, Yu X, Yu Y, Wang L, Dong M: Analysis of expressed sequence tags from the venom ducts of Conus striatus: focusing on the expression profile of conotoxins. ''Conus geographus'', popularly called the geography cone or the geographer cone, is a species of predatory cone snail. Genomics.
1997, 99 (10): 2538-2544. Edited by: Lazarovici E, Spira ME, Zlotkin . Bioinformatics. Nucleic Acids Res. Therefore, for each contig in our reference transcriptome, we used a chi-square test to calculate The sequence data from this study are submitted to the NCBI Sequence Read Archive (Fragments Per Kb exon model per Million mapped reads.Olivera BM: Conus venom peptides, receptor and ion channel targets and drug design: 50 million years of neuropharmacology (E.E. The fish-hunting cone snail, Conus geographus, is the deadliest snail on earth.
Conus geographus Linnaeus, 1758. Studies by Garrett et al. The higher affinity site for alpha-conotoxin GI is the alpha/delta site on mouse muscle-derived BC3H-1 receptor, and the other site (alpha/gamma site) on nicotinic receptors from Torpedo californica electric organ. J Biol Chem. 10.1038/nbt.1621.Robinson MD, Oshlack A: A scaling normalization method for differential expression analysis of RNA-seq data. With its lovely brown-and-white shell, the marine snail known as the geography cone (Conus geographus) may not look very lethal or threatening at first glance. The venom paralyzes … This is risky, because the snail often fires its harpoon in these situations.
Biochem Biophys Res Commun. These data are presented in Table To further investigate the functional implications of these differences in segment expression profiles, we also examined the differential expression of InterPro protein families. 2009, 25 (14): 1754-1760.
1988, 27 (17): 6256-6262.
We have used transcriptome sequencing to systematically elucidate the contents the Cone snails are venomous predators that rapidly immobilize their prey using a complex cocktail of short peptides (10–40 AA long) collectively known as conotoxins. Just Lecture, 1996).